Browse the search results

Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.

Integrative structural analyses of human insulin degradingenzyme (IDE) reveal how IDE selectively degrades peptides that form toxicaggregates, which guides IDE-based therapeutic innovations to treat diabetesand Alzheimer's disease.

Human intracranial electroencephalographic recordings reveal the electrophysiological properties and hierarchical organization of spontaneous neuronal oscillations in the human insula and show that these oscillations are traveling waves, thus providing new insights into intrainsular and interinsular communication.

By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.

Anterior insular cortex activity predicts how well we attend to our bodily signals, while lesions to this brain region disrupt this ability.

Profiling the adipocyte secretome reveals LRG1 as a novel adipokine that promotes insulin sensitivity and modulates inflammation triggered by release of cytochrome c from dead/dying cells, describing a new pathway at the intersection of obesity and its systemic sequelae.

Behavioral electrophysiology and optogenetics studies reveal that projections from the anterior insula to the medial thalamus mitigate fear, while projections to the amygdala promote fear.

Live cell imaging shows that the cAMP-sensor Epac2, a target of major antidiabetic drugs, is central to fusion pore control during insulin granule exocytosis.

Utilizing a conserved mechanism, a ribosome can initiate translation from a site within the insulin receptor mRNA to maintain protein synthesis even when standard mechanisms of initiating translation have been inhibited by stress.

At adhesion sites, talin-activated vinculin promotes interactions with the actin network that initiates bundles.