Distinct phosphorylations of Akt determine the regulation of glucose uptake into fat and epithelial cells, revealing unexpected specialization in both Akt activation and its downstream control of glucose metabolism.
A cytokine partly derived from macrophages is required to promote normal muscle health and metabolism by inhibiting the activity of the insulin signalling pathway in the fruitfly Drosophila melanogaster.
Individual cells display heterogeneous fluctuations in metabolic activity, with amplitude and kinetics controlled by interlocking feedbacks between glycolysis and the Insulin/PI3K/Akt signaling pathway.
Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
A structure of a pancreatic ATP-sensitive potassium channel complex at 3.63Å resolution obtained by cryo-electron microscopy reveals how a commonly used anti-diabetic drug interacts with and inhibits the channel to stimulate insulin secretion.