2,010 results found
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
    1. Neuroscience

    Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy

    Thomas Ridler et al.
    Dementia-related tau pathology reduces speed encoding in the medial entorhinal cortex and is associated with reduced grid cell function, whilst head direction tuning remains intact.
    1. Structural Biology and Molecular Biophysics

    Structural basis for SARM1 inhibition and activation under energetic stress

    Michael Sporny et al.
    Cryo-EM shows that the NADase activity of SARM1 is allosterically inhibited by physiological concentrations of NAD+ that stabilizes an auto-inhibited conformation of SARM1, explaining how NAD+ depletion may inflict neurodegeneration.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

    Allen Wang et al.
    Generation of a human lung single nucleus ATAC-seq and single nucleus RNA-seq datasets reveals candidate cis-regulatory elements that advance knowledge on gene expression control in normal and diseased lungs.
    1. Neuroscience

    Fine-scale computations for adaptive processing in the human brain

    Elisa Zamboni et al.
    Laminar fMRI reveals that adaptive processing involves recurrent processing within visual cortex and top-down influences from posterior parietal cortex via feedback.
    1. Stem Cells and Regenerative Medicine

    Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells

    Balyn W Zaro et al.
    Mass spectrometry exposes a post-transcriptionally regulated reduction in protein diversity in hematopoietic stem cells, including a lack of detectable Dnmt3a protein levels despite mRNA levels comparable to progenitors.
    1. Ecology
    2. Physics of Living Systems

    Efficient mate finding in planktonic copepods swimming in turbulence

    François-Gaël Michalec et al.
    Calanoid copepods achieve efficient mate finding in turbulence through active swimming and turbulence advection, indicating that reproduction is not restricted to spatial and temporal windows of calm hydrodynamic conditions.
    1. Neuroscience

    Extended field-of-view ultrathin microendoscopes for high-resolution two-photon imaging with minimal invasiveness

    Andrea Antonini et al.
    Aberration correction using 3D microprinting in ultrathin microendoscopes allows two-photon imaging of large neuronal networks with homogeneously high spatial resolution and minimal invasiveness in the deep mouse brain.
    1. Genetics and Genomics

    Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross

    Kaushik Renganaath et al.
    Yeast promoters can harbor multiple natural DNA variants that influence gene expression, interact genetically, evolve under negative selection, alter transcription factor motifs, and remain challenging to predict.
    1. Cell Biology

    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation

    Maria Fomicheva, Ian G Macara
    TRAF3, a negative regulator of noncanonical NF-κB signaling, maintains epithelial cell quiescence at confluence, and its loss triggers upregulation of immunity genes and prevents entry into G0 at high cell density.

Refine your results by:

Type
Research categories