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Page 2 of 363
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Prediction of enzymatic pathways by integrative pathway mapping

    Sara Calhoun et al.
    A computational method identifies the functions of orphan enzymes by organizing them into metabolic pathways; the prediction of a new l-gulonate catabolic pathway is experimentally tested and confirmed.
    1. Neuroscience

    Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development

    Hanqing Li et al.
    A network, composed of 22 relatives of the Beaten Path and Sidestep immunoglobulin superfamily cell surface proteins, also includes several neuronal Beaten Path subfamily receptors which interact selectively with Sidestep subfamily proteins expressed on peripheral tissues.
    1. Human Biology and Medicine

    Integrative genomic analysis of the human immune response to influenza vaccination

    Luis M Franco et al.
    By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.
    1. Neuroscience

    The right hippocampus leads the bilateral integration of gamma-parsed lateralized information

    Nuria Benito et al.
    High-resolution electrode recordings reveal left-right asymmetry in hippocampal gamma waves.
    1. Microbiology and Infectious Disease

    Differential interaction forces govern bacterial sorting in early biofilms

    Enno R Oldewurtel et al.
    Differential physical interactions between bacteria in mixed microcolonies trigger cell sorting.
    1. Neuroscience

    Perception of social interaction compresses subjective duration in an oxytocin-dependent manner

    Rui Liu et al.
    The subjective time of social interactions reflects one's autistic-like tendency and is critically mediated by oxytocin, indicating that time perception is ingrained with personality traits, which likely have neuroendocrine origins as per previous research.
    1. Computational and Systems Biology

    The genetic landscape of a physical interaction

    Guillaume Diss, Ben Lehner
    First comprehensive analysis of how many different mutations combine within and between two genes to alter a molecular phenotype.
    1. Neuroscience

    The modulation of neural gain facilitates a transition between functional segregation and integration in the brain

    James M Shine et al.
    The flexible network architecture of the brain is sensitive to the modulation of neural gain, which may be mediated by ascending arousal nuclei, such as the noradrenergic locus coeruleus.
    1. Neuroscience

    Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons

    Jegath C Athilingam et al.
    Serotonin changes passive membrane properties in prefrontal fast-spiking interneurons to affect not only neuronal excitability but also the temporal filtering of synaptic inputs with a preference for gamma-frequency summation.
    1. Neuroscience

    Energy exchanges at contact events guide sensorimotor integration

    Ali Farshchian et al.
    The brain obtains and preserves a consistent temporal alignment of multisensory and motor information flowing along staggered streams by maintaining an invariant estimate across modalities of the energy exchanged with the environment at discrete events.