Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.
The molecular regulatory mechanisms that control the interaction between mesenchymal stem cells and transit amplifying cells to maintain tissue homeostasis.
Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell
RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
A neuroanatomical analysis of Rimicaris exoculata provides insights into these animal’s brain architecture to illustrate possible adaptations to the hydrothermal vent habitat with its extreme physicochemical conditions.
Ezh2 and Arid1a oppose each other to control expression of Cdkn2a to coordinate tooth furcation development and ultimately determine the number of roots in mouse molars.
Thuy-Lan V Lite, Robert A Grant ... Michael T Laub
A generalizable approach to understanding the logic of molecular recognition reveals the contributions of individual residues to the specificity of protein-protein interactions.
Corey Fernandez, Jiefeng Jiang ... Anthony D Wagner
Mnemonic mechanisms of differentiation and integration within the medial temporal lobe occur concurrently during the learning of local and global environmental knowledge.
George A Spirou, Matthew Kersting ... Paul B Manis
Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.
