187 results found
    1. Microbiology and Infectious Disease

    A mobile genetic element increases bacterial host fitness by manipulating development

    Joshua M Jones et al.
    A mobile genetic element provides a selective advantage to host cells by delaying development, including biofilm and spore formation, thereby enabling temporary cheating and extra divisions.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An analog to digital converter controls bistable transfer competence development of a widespread bacterial integrative and conjugative element

    Nicolas Carraro et al.
    A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Slightly beneficial genes are retained by bacteria evolving DNA uptake despite selfish elements

    Bram van Dijk et al.
    Horizontal gene transfer (HGT) helps slightly beneficial genes persist in microbial populations, incentivising cells to invest in costly DNA uptake, even in the presence of harmful selfish genetic elements.
    1. Ecology
    2. Genetics and Genomics

    Viral dark matter and virus–host interactions resolved from publicly available microbial genomes

    Simon Roux et al.
    From public microbial genomes, VirSorter revealed 12,498 viral genome sequences that expand the map of the global virosphere and whose analyses improve understanding of viral taxonomy, evolution and virus-host interactions.
    1. Neuroscience

    Neural representation of abstract task structure during generalization

    Avinash R Vaidya et al.
    The human brain maintains a representation of latent task states within frontoparietal networks during the generalization of behaviors to novel settings.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Extensive horizontal gene transfer in cheese-associated bacteria

    Kevin S Bonham et al.
    The identification of horizontally transferred genes, and commonly transferred functions, can provide a window into the selective forces acting on species within an ecosystem.
    1. Cancer Biology
    2. Genetics and Genomics

    MITF reprograms the extracellular matrix and focal adhesion in melanoma

    Ramile Dilshat et al.
    Analysis of knockout and knockdown melanoma cells and TCGA melanoma data shows that the microphthalmia-associated transcription factor (MITF) is a major repressor of extracellular matrix (ECM) and focal adhesion genes.
    1. Evolutionary Biology

    Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

    José Antonio Escudero et al.
    The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
    1. Microbiology and Infectious Disease

    Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

    Giancarlo Noe Bruni, Joel M Kralj
    Aminoglycosides are a class of antibiotics that can kill Escherichia coli by building up internal voltage through disrupting the normal consumption of ATP.
    1. Cell Biology

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.

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