1,229 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex

    Ursula Schulze-Gahmen et al.
    The crystal structure of the trans-activation response region (TAR) bound to HIV-1 Tat and an elongation factor, together with HDX, SHAPE, SAXS, and integrative modeling, shows how TAR binds this complex in two ways.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of the yeast Mediator complex

    Philip J Robinson et al.
    Integrative modeling of results from chemical cross-linking, electron microscopy, and homology modeling yield a three-dimensional model of the entire Mediator complex in yeast.
  1. Point of View: Correcting the bias against interdisciplinary research

    Ehud Shapiro
    When making decisions about funding and jobs the scientific community should recognise that most of the tools used to evaluate scientific excellence are biased in favour of established disciplines and against interdisciplinary research.
    1. Cell Biology
    2. Computational and Systems Biology

    Heat Shock Response: A model for handling cell stress

    Laura Le Breton, Matthias P Mayer
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    1. Developmental Biology

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach et al.
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Neuroscience

    Sound localization: These are not the neurons you are looking for

    Victor Benichoux, Daniel J Tollin
    Studies that looked into how the auditory brainstem processes the difference in the intensity of a sound as it reaches each ear may have wrongly assumed which neurons were being recorded.
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    1. Neuroscience

    Autism: Exploring the social brain

    John P Welsh, Annette M Estes
    How does the brain physiology of young children with autism differ from that of typically-developing children?.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.

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