250 results found
    1. Medicine

    Bone circuitry and interorgan skeletal crosstalk

    Mone Zaidi, Se-Min Kim ... Tony Yuen
    Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.
    1. Developmental Biology
    2. Evolutionary Biology
    Silhoutte of a coqui frog in black on a purple background.

    The Natural History of Model Organisms: The big potential of the small frog Eleutherodactylus coqui

    Sarah E Westrick, Mara Laslo, Eva K Fischer
    The coquí frog is of interest to researchers in fields as diverse as development biology, social behavior and the biology of invasive species.
    1. Neuroscience

    Autism: Exploring the social brain

    John P Welsh, Annette M Estes
    How does the brain physiology of young children with autism differ from that of typically-developing children?.
    Version of Record
    Insight
    1. Ecology
    2. Evolutionary Biology

    Thermal acclimation of tropical coral reef fishes to global heat waves

    Jacob L Johansen, Lauren E Nadler ... Jodie Rummer
    The ability of animals to adjust to thermal stress is critical for survival under global warming, yet the adjustment process and scope have (until now) remained obscure in marine fishes.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

    Samuel J Modlin, Derek Conkle-Gutierrez ... Faramarz Valafar
    Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

    Flora Mikaeloff, Marco Gelpi ... Ujjwal Neogi
    Multi-omics-driven patient stratification identify at-risk profile of metabolic complications in people living with HIV on suppressive therapy that need clinical attention.
    1. Cell Biology
    2. Neuroscience

    A spatial threshold for astrocyte calcium surge

    Justin Lines, Andres Baraibar ... Alfonso Araque
    In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integration of time and space.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO hyperactivity drives premature aging of Norad-deficient mice

    Florian Kopp, Mahmoud M Elguindy ... Joshua T Mendell
    Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.
    1. Neuroscience

    Functional brain reconfiguration during sustained pain

    Jae-Joong Lee, Sungwoo Lee ... Choong-Wan Woo
    Human neuroimaging with time-evolving network analysis reveals dynamic interactions among multiple functional brain networks in response to sustained pain.
    1. Neuroscience

    Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

    Justin K O'Hare, Haofang Li ... Nicole Calakos
    Fast-spiking interneurons of the dorsolateral striatum are found to provide a microcircuit mechanism driving the circuit properties and behavioral adaptations that characterize habit.

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