57 results found
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Physics of Living Systems
    2. Cell Biology

    27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells

    Lei Zhang, Yubin Hou ... Xin Zhang
    An ultra-high static magnetic field changes mitotic spindle orientation in cells by exerting magnetic torques on both microtubules and chromosomes.
    1. Computational and Systems Biology

    Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis

    Krutik Patel, Matt Barter ... Daryl P Shanley
    A multi-disciplined approach uncovered microRNA-199a/b-5p as important regulators of chondrogenesis, which negatively regulate mRNAs such as FZD6, ITGA3, and CAV1 for protective purposes during chondrogenesis.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity

    Rebecca LaCroix, Benjamin Lin ... Andre Levchenko
    The regulatory subunit of protein kinase A (PKA) can both activate and suppress the PKA activity at the plasma membrane, with its graded membrane localization capable of inducing a switch in cell migration.
    1. Cancer Biology
    2. Immunology and Inflammation

    Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

    Matheswaran Kandasamy, Uzi Gileadi ... Vincenzo Cerundolo
    Immunization with NY-ESO-1 S-FLU virus elicits a robust NY-ESO-1-specific CTL response and suppresses the NY-ESO-1-expressing tumour development and spontaneous metastasis.
    1. Cell Biology

    Secreted exosomes induce filopodia formation

    Caitlin McAtee, Mikin Patel ... Alissa M Weaver
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization

    Peter L Lee, Maikke B Ohlson, Suzanne R Pfeffer
    Rab6A binds directly to both the C-terminus and the N-terminal motor domain of the kinesin KIF1C to regulate vesicle motility and Golgi organization.
    1. Cell Biology

    Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

    Sagnik Pal, Yangyang Su ... Mark Richards
    Not revised
    Reviewed Preprint v1
    • Useful
    • Inadequate
    1. Cell Biology
    2. Microbiology and Infectious Disease

    ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly

    Snježana Mikuličić, Jérôme Finke ... Luise Florin
    ADAM17 is a key player in the non-canonical endocytosis pathway that is used by oncogenic papillomaviruses as it allows virus/receptor platform assembly by activation of the ERK1/2 signaling pathway.
    1. Developmental Biology

    Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification

    Imran S Khan, Christopher Molina ... Dean Sheppard
    Reduced lung myofibroblast proliferation is a unifying feature in multiple models of developmental emphysema and inhibition of myofibroblast proliferation is sufficient to cause this pathology.

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