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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Juxtaposition of heterozygous and homozygous regions causes reciprocal crossover remodelling via interference during Arabidopsis meiosis

    Piotr A Ziolkowski, Luke E Berchowitz ... Ian R Henderson
    Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.
    1. Neuroscience

    Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses

    Bernard Bloem, Rafiq Huda ... Ann M Graybiel
    Simultaneous 2-photon imaging of striosomes and matrix in mice shows that striosomes preferentially encode reward-predicting cues whereas both striatal compartments demonstrate reward-related activity.
    1. Epidemiology and Global Health

    Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study

    Gayathri Nagaraj, Shaveta Vinayak ... Dimpy P Shah
    Sociodemographic (age, race/ethnicity) and clinical (Eastern Cooperative Oncology Group performance status, pre-existing comorbidities, and active and progressing cancer) risk factors were associated with worse COVID-19 outcomes in patients with breast cancer.
    1. Developmental Biology

    Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

    Pankaj Sahai-Hernandez, Claire Pouget ... David Traver
    A rare population of endothelial cells emerges from a bipotent muscle progenitor population in the paraxial mesoderm and provides niche support to induce hematopoietic stem cells.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Mechanically transduced immunosorbent assay to measure protein-protein interactions

    Christopher J Petell, Kathyrn Randene ... Joshua P Steimel
    METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.
    1. Developmental Biology
    2. Neuroscience

    MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex

    Wei Zhang, Paul Jong Kim ... Li Zeng
    During early cortical development, microRNA-128 regulates the homeostasis of neural stem cells by targeting PCM1, a protein that is critical for cell division.
    1. Structural Biology and Molecular Biophysics

    The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

    Alexandria N Miller, Patrick R Houlihan ... David E Clapham
    SARS coronaviruses encode several mysterious proteins such as Orf3a and, in contrast to what has been claimed, Orf3a is not an ion channel but rather disrupts cellular trafficking by binding to the protein sorting complex known as HOPS.
    1. Developmental Biology
    2. Neuroscience

    The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

    Sebastián Giunti, María Gabriela Blanco ... Diego Rayes
    PTEN mutations disrupt inhibitory GABAergic signaling, causing neurodevelopmental defects that can be mitigated by β-hydroxybutyrate, which activates DAF-16/FOXO and may offer a therapeutic approach for excitation/inhibition imbalances.
    1. Neuroscience

    A spiral attractor network drives rhythmic locomotion

    Angela M Bruno, William N Frost, Mark D Humphries
    The neural population of the Aplysia's pedal ganglion are a low-dimensional spiral attractor, and the parameters of the attractor directly define the properties of the Aplysia's escape locomotion behaviour.
    1. Microbiology and Infectious Disease

    Dynamics of macrophage polarization support Salmonella persistence in a whole living organism

    Jade Leiba, Tamara Sipka ... Mai E Nguyen-Chi
    Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.