4,453 results found
    1. Neuroscience

    Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior

    Alberto Llera et al.
    Multi-modal structural data fusion questions the specificity of fMRI-behavior associations by providing strong evidence relating human brain structure to a wide range of behavioral measures previously associated to functional connectivity.
    1. Developmental Biology

    Embryonic geometry underlies phenotypic variation in decanalized conditions

    Anqi Huang et al.
    Gene regulatory networks incorporate information of the embryonic geometrical parameters to give rise to differential individual patterning outputs under decanalized genetics backgrounds.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CRISPR-based functional genomics in human dendritic cells

    Marco Jost et al.
    A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
    1. Microbiology and Infectious Disease

    Stochastic variation in the initial phase of bacterial infection predicts the probability of survival in D. melanogaster

    David Duneau et al.
    An analysis of within-host bacterial proliferation reveals that minor "stochastic" variation in the ability of the innate immune response to control bacterial growth early on can result in either survival or death of the host.
    1. Neuroscience

    Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex

    Hugh Pastoll et al.
    Setpoints that determine the integrative properties of neurons in the medial entorhinal cortex are established at a population level and differ between animals.
    1. Genetics and Genomics

    Passive and active DNA methylation and the interplay with genetic variation in gene regulation

    Maria Gutierrez-Arcelus et al.
    Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression variability in human and chimpanzee populations share common determinants

    Benjamin Jung Fair et al.
    Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-quality carnivoran genomes from roadkill samples enable comparative species delineation in aardwolf and bat-eared fox

    Rémi Allio et al.
    High-quality genomes can be obtained from roadkill samples and used in population genomics for species delimitation with conservation implications.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky et al.
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Neuroscience

    Improving a probabilistic cytoarchitectonic atlas of auditory cortex using a novel method for inter-individual alignment

    Omer Faruk Gulban et al.
    Inter-individual human brain alignment that uses macro-anatomical priors in addition to cortical curvature improves micro-anatomical correspondence between auditory areas.

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