744 results found
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu et al.
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Genetics and Genomics

    Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo

    Manon Baëza et al.
    Short peptide motifs can confer specificity to developmental networks by inhibiting protein–protein interactions.
    1. Neuroscience

    Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition

    Vivek Mahadevan et al.
    Unbiased functional proteomics reveal that protein interactions are a key regulator of the strength of synaptic inhibition in neurons of the central nervous system.
    1. Neuroscience

    A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

    Cristian A Lasagna-Reeves et al.
    Studies in a mouse model of spinocerebellar ataxia type 1 show that a protein called capicua stabilizes toxic ataxin-1 oligomers offering a possible explanation for regional patterns of neurodegeneration.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina et al.
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Cell Biology
    2. Neuroscience

    The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

    Heather S Comstra et al.
    The ATP7A interactome is the first comprehensive view of putative Menkes disease neurodegeneration mechanisms.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

    Luis V Nobre et al.
    The human cytomegalovirus (HCMV) interactome systematically characterises high-confidence viral-viral and viral-host protein interactions in HCMV-infected cells, facilitating multiple novel insights into HCMV and herpesviral function.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries

    Michael Luke Carlson et al.
    Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation

    Arda Halu et al.
    Enriching the interactome with context-specific information from proteomics helps the identification of novel regulators of macrophage activation.
    1. Biochemistry and Chemical Biology

    Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms

    Michal Ziemski et al.
    Cdc48-like protein of actinobacteria (Cpa) is a AAA+ proteasomal interactor involved in adaptation of mycobacteria to carbon limitation and potentially influencing ribosomal composition of the cell.

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