526 results found
    1. Microbiology and Infectious Disease

    Mechanistic Microbiome Studies: A Special Issue

    Curated by Wendy S Garrett et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of microbiome function.
  1. Meta-research

    Meta-Research: A Collection of Articles

    Curated by Peter Rodgers
    The study of science itself is a growing field of research.
  2. Episode 46: March 2018

    In this episode, we hear about autism, insulin resistance, Sci-Hub, coping with low levels of oxygen, and how the brain responds to blindness.
    1. Computational and Systems Biology

    Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting

    David Mavor et al.
    Chemical perturbation-dependent deep mutational scanning data collected by a lab-based interdisciplinary graduate class resolves a paradox between the high evolution conservation and the high mutational tolerance of the protein ubiquitin.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling

    Rajan Thakur et al.
    Phosphatidic acid regulates recycling of endocytosed plasma membrane vesicles in polarized cells through a retromer and Arf1 dependent process.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Conservation of transcription factor binding specificities across 600 million years of bilateria evolution

    Kazuhiro R Nitta et al.
    Drosophila has almost all transcription factor binding specificities available to humans; and human transcription factors with divergent specificities operate in cell types that are not found in fruit flies.
    1. Cell Biology

    Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2

    Mario Ruiz et al.
    Inhibition of C. elegans FLD-1 or Human TLCD1/2 prevents saturated fat lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.
    1. Neuroscience

    The influence of task outcome on implicit motor learning

    Hyosub E Kim et al.
    During a sensorimotor perturbation, task outcome may serve as a gain on implicit adaptation or provide a distinct error signal for a second, independent implicit learning process.
    1. Neuroscience

    Value-based attentional capture affects multi-alternative decision making

    Sebastian Gluth et al.
    Speeded value-based decisions between two options can be affected by a third, high-value distractor that captures attention and slows down the choice process.
    1. Human Biology and Medicine
    2. Neuroscience

    Characterizing a psychiatric symptom dimension related to deficits in goal-directed control

    Claire M Gillan et al.
    A dimensional approach to psychiatry demonstrates the specificity and generalizability of a neurocognitive marker of compulsive behavior and intrusive thought via large-scale online testing.

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