350 results found
    1. Neuroscience

    Robust vestibular self-motion signals in macaque posterior cingulate region

    Bingyu Liu et al.
    Macaque posterior cingulate region carries vestibular dominant self-motion signals with plentiful temporal components that could be useful for process of path integration.
    1. Neuroscience

    Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

    Stephanie C Gantz et al.
    Modifying membrane potential by an 'inhibitory' chloride conductance such as PSAM4-GlyR is inherently unstable because the normally low intracellular concentration of chloride is readily increased by influx of chloride.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Eitan Lerner et al.
    A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.
    1. Medicine

    Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

    Wanxia Gai et al.
    Epigenetic determination of tissue of origin of genetically classified subsets of plasma DNA molecules enhances transplantation monitoring and cancer testing.
    1. Immunology and Inflammation
    2. Medicine

    Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

    Ada Weinstock et al.
    Wnt signaling is revealed to be a regulator of macrophage inflammation-resolving state in atherosclerosis through a PGE2-mediated pathway.
    1. Neuroscience

    A spinoparabrachial circuit defined by Tacr1 expression drives pain

    Arnab Barik et al.
    A circuit involving Tacr1-expressing neurons in the spinal cord and the parabrachial nucleus controls how mice respond to a wide range of persistently painful stimuli.
    1. Genetics and Genomics

    Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

    Swati Gaikwad et al.
    A mutant impaired for ribosome recycling exhibits translational reprogramming wherein strong mRNAs outcompete weak mRNAs, also observed when preinitiation complexes are diminished by eIF2α phosphorylation or 40S ribosomal subunit depletion.
    1. Neuroscience

    Performance in even a simple perceptual task depends on mouse secondary visual areas

    Hannah C Goldbach et al.
    In a simple visual task, that in principle could be performed using information in V1 alone, perturbations of secondary visual areas impair perception.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

    Taylor B Updegrove et al.
    Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved to use ATP.
    1. Immunology and Inflammation

    Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

    Rabina Mainali et al.
    Integrative multi-omics reveals global dysregulation in hepatic metabolism during prolonged sepsis.

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