291 results found
    1. Developmental Biology
    2. Neuroscience

    Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

    Francesco A Servello, Rute Fernandes ... Javier Apfeld
    C. elegans nematodes can assess faithfully the threat that H2O2 poses by coupling the induction of their H2O2 defenses to the perception of high temperature—an inherent enhancer of the reactivity of H2O2.
    1. Computational and Systems Biology

    Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers

    Matthias Bauer, Johannes Knebel ... Erwin Frey
    Quorum sensing enables heterogeneous production of autoinducers in microbial populations, suggesting an alternative mechanism to stochastic gene expression in bistable gene-regulatory circuits to control phenotypic heterogeneity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Molecular basis of the PIP2-dependent regulation of CaV2.2 channel and its modulation by CaV β subunits

    Cheon-Gyu Park, Wookyung Yu, Byung-Chang Suh
    The anchoring properties of CaV β2 subunits to the plasma membrane determine the biophysical states of CaV2.2 channels by regulating PIP2 coupling to the nonspecific phospholipid-binding site in the I–II loop.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective

    Joseph Ackermann, Chiara Bernard ... Martine Ben Amar
    Revised
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    1. Developmental Biology
    2. Physics of Living Systems

    Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development

    Lokesh G Pimpale, Teije C Middelkoop ... Stephan W Grill
    Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.
    1. Developmental Biology
    2. Plant Biology

    Temporal integration of auxin information for the regulation of patterning

    Carlos S Galvan-Ampudia, Guillaume Cerutti ... Teva Vernoux
    Rhythmic centrifugal waves of auxin traveling through the tissue provides high definition positional information to cells that is not only spatial but also temporal.
    1. Cell Biology
    2. Plant Biology

    From plasmodesma geometry to effective symplasmic permeability through biophysical modelling

    Eva E Deinum, Bela M Mulder, Yoselin Benitez-Alfonso
    A new biophysical model enables the reconciliation of ultrastructural and tissue level measurements on parameters affecting intercellular communication, and provides novel functional insight into experimental findings.
    1. Developmental Biology

    The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila

    Leonard Drees, Susi Schneider ... Matthias Behr
    Genetic analyses reveal the importance of dynamic protein processing at the apical cell membrane in response to forces damaging cell membranes during tube expansion in tubular organs.
    1. Developmental Biology
    2. Neuroscience

    Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

    Meike E van der Heijden, Elizabeth P Lackey ... Roy V Sillitoe
    Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.
    1. Immunology and Inflammation

    Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

    Javier Ruiz-Navarro, Sara Fernández-Hermira ... Manuel Izquierdo Pastor
    FMNL1β is phosphorylated on S1086 in a protein kinase C δ (PKCδ)-dependent manner and S1086-phosphorylated FMNL1β acts downstream of PKCδ to regulate centrosome and multivesicular bodies polarization to the immunological synapse and exosome release.

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