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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue et al.
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    1. Cell Biology
    2. Developmental Biology

    The beetle amnion and serosa functionally interact as apposed epithelia

    Maarten Hilbrant et al.
    Late morphogenesis of the insect extraembryonic epithelia involves transient formation of a basal-basal bilayer to coordinate the functional contributions of two discrete tissues.
    1. Microbiology and Infectious Disease

    A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

    Alyson Ashe et al.
    Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

    Kelly M Storek et al.
    Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

    Victoria E Pedanou et al.
    A large-scale RNA interference screen uncovers a new transcriptional regulatory program involving the histone H3 demethylase KDM3A, which mediates detachment-induced apoptosis (anoikis) in breast epithelial cells.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

    Jeroen Overman et al.
    A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions is reported.
    1. Neuroscience

    Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex

    Cheng Tang et al.
    The evidence of subspace computation in the lateral prefrontal cortex provides insights into the neural mechanisms underlying cognitive flexibility and interference between different cognitive processes.
    1. Computational and Systems Biology
    2. Neuroscience

    A sensorimotor model shows why a spectral jamming avoidance response does not help bats deal with jamming

    Omer Mazar, Yossi Yovel
    An elaborated bat-predator model shows that even in high bat-densities, bats can successfully catch flying insects and that changing their signals’ frequency is not necessary for dealing with sensory interference.
    1. Chromosomes and Gene Expression

    CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

    Françoise S Howe et al.
    CRISPR interference (CRISPRi), which uses small guide RNAs to target catalytically dead Cas9 protein to chromatin, disrupts existing transcription units and generates new sites for initiation and termination of transcription on both strands of DNA.
    1. Chromosomes and Gene Expression

    Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis

    Todd Blevins et al.
    The 24-nucleotide long siRNAs that guide cytosine methylation in Arabidopsis are made by dicing short double-stranded RNAs that are only around 30 nucleotides long.