CapZ controls actin filament density around immature early endosomes via its C-terminal domain to facilitate the homotypic fusion of the endocytic vesicles, and it functions as a scaffold protein via its N-terminal domain to recruit RAB5 effectors to early endosomes.

Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.

Independent dating techniques have established that the H. naledi fossils are between 236 and 335 thousand years old, indicating that small-brained hominins with relatively primitive body shapes co-existed with our early ancestors in Africa.

The two most commonly used chemogenetic actuators, clozapine-N-oxide and compound 21, similarly modulate sleep in wild-type laboratory mice indicating that even designer drugs which do not convert to clozapine can elicit behavioural effects and require adequate controls.

Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.

Intraspecific predator interference enables a wide range of consumer species to coexist with a limited variety of resources, explaining the paradox of the plankton and species diversity patterns across ecosystems.

An inferred mechanistic model that connects sequence (genotype) to function (constitutive gene expression phenotype) for any random sequence in Escherichia coli reveals the structure of constitutive promoters and how they evolve.