28 results found
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

    Martin H Fabry et al.
    Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
    1. Genetics and Genomics

    An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

    Tom G Richardson et al.
    A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.
    1. Developmental Biology
    2. Neuroscience

    Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila

    Marion Langen et al.
    The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity

    Anjar Wibowo et al.
    Transient adaptation to environmental fluctuations in plants is mediated through discrete epigenetic changes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection

    Bryan L Gitschlag et al.
    Food supply and nutrient stress tolerance coordinately shape the multilevel selection dynamics of a mitochondrial cheater by promoting cheater persistence at both within-host and between-host levels of selection.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans

    L Ryan Baugh, Troy Day
    Evidence is mounting that environmentally-induced adaptive changes in phenotype can be transmitted across generations, but mechanistic gaps and theoretical concerns must be addressed to impact mainstream views of evolutionary adaptation.
    1. Cell Biology

    Serotonin signaling by maternal neurons upon stress ensures progeny survival

    Srijit Das et al.
    Neuronal serotonin release tunes transcription response times of Caenorhabditis elegans germ cells to promote the survival and stress resistance of future offspring.
    1. Computational and Systems Biology

    Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees

    Erika E Kuchen et al.
    The combination of statistical inference and perturbation experiments reveals that trans-generational inheritance of cell size and cell-cycle speed, coupled through a minimum-size checkpoint, shapes paradoxical cell-cycle correlations in lineage trees.
    1. Physics of Living Systems

    Surface-to-volume scaling and aspect ratio preservation in rod-shaped bacteria

    Nikola Ojkic et al.
    Rod-shaped bacteria preserve their aspect ratios and surface-to-volume scaling by maintaining a homeostatic balance between the rates of cell elongation and division protein synthesis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson et al.
    Among the factors that predict fitness in wild baboons, dominance rank in males, but not in females, is the best predictor of epigenetic aging.

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