407 results found
    1. Developmental Biology
    2. Neuroscience

    The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors

    Yonggang Xie et al.
    The Drosophila equivalent of the human transcription factor Sp8 acts to ensure that neural progenitor cells undergo an appropriate number of cell divisions, thereby helping to regulate brain development and guard against tumor formation.
    1. Developmental Biology
    2. Neuroscience

    Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

    Branden R Nelson et al.
    Multiphoton live-imaging illuminates the dynamic underpinnings of how different types of progenitor cells migrate and interact to robustly build the mammalian Dentate Gyrus neural circuitry and new outer neurogenic niche.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1

    Anna E Hakes, Andrea H Brand
    Increased expression of Drosophila Tailless (TLX homologue) reverts intermediate progenitors to neural stem cells, inducing tumourigenesis via Asense repression and reflecting mutually exclusive TLX and ASCL1 expression in human glioblastoma.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

    Chwee Tat Koe et al.
    A novel complex composed of various components of a chromatin remodeling complex, a chromatin remodeling factor and a transcription factor suppresses the dedifferentiation of intermediate neural progenitors back into neuroblasts in Drosophila.
    1. Stem Cells and Regenerative Medicine

    Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor Buttonhead

    Hideyuki Komori et al.
    The Drosophila equivalent of the human protein Mixed Lineage Leukemia 1n enables neural stem cells to generate neural progenitors through the fly equivalent of the human transcription factor Sp8, thereby contributing to an increased number and diversity of cell types during brain development.
    1. Stem Cells and Regenerative Medicine

    Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

    Hyunah Lee et al.
    Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
    1. Cancer Biology
    2. Developmental Biology

    Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila

    Karine Narbonne-Reveau et al.
    Sequentially expressed temporal transcription factors in neural stem cells during early development determine which progeny can undergo malignant transformation upon dedifferentiation.
    1. Neuroscience

    Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells

    Christina Chatzi et al.
    Neural progenitors reside in relative low oxygen in the subgranular zone (SGZ), and the higher tissue oxygen levels that these cells must face as they migrate away from the hypoxic areas and differentiate appear to cause oxidative damage and an early phase of cell death.
    1. Developmental Biology

    Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila

    Satish Kumar Tiwari et al.
    Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in Drosophila..
    1. Neuroscience

    Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

    Achira Roy et al.
    Acute one-hour treatment of Pik3ca mutant mice with a novel anti-epilepsy drug suppresses seizures despite continued developmental brain dysmorphology, promising a new therapeutic strategy for patients with intractable pediatric epilepsy.

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