327 results found
    1. Evolutionary Biology

    Symptom evolution following the emergence of maize streak virus

    Adérito L Monjane et al.
    Phylogenetic analyses demonstrate an evolutionary trade-off between the amount of harm inflicted by a broad host-range virus and how effectively the virus positions itself within plants to enable onward transmission.
    1. Developmental Biology
    2. Neuroscience

    Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

    Luis Sánchez-Guardado, Carlos Lois
    Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
    1. Microbiology and Infectious Disease

    The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

    Ashley M Ngo et al.
    The ER membrane protein complex (EMC) facilitates the correct topology of the flavivirus non-structural proteins NS4A and NS4B at the ER membrane critical for viral replication.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

    Anneke Dixie Kakebeen et al.
    Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells

    Despoina Mademtzoglou et al.
    Ablation of the Cdkn1c cell cycle inhibitor leads to defective muscle stem cell dynamics and myogenic potential, while progressive cytoplasmic to nuclear cellular localization of the Cdkn1c protein regulates growth arrest.
    1. Developmental Biology
    2. Neuroscience

    Neuronal cell fate diversification controlled by sub-temporal action of Kruppel

    Johannes Stratmann et al.
    A combination of temporal and sub-temporal genes combine to move the stem cell through different competence windows to generate different cell types at different time-points in Drosophila.
    1. Neuroscience

    Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

    Mar Gacias et al.
    Gut microbiota can influence mPFC transcriptional profiles and myelin content, overriding the impact of genetic background in the development of social avoidance behavior.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

    Benjamin Werner et al.
    Telomere length distributions can be used to infer important properties of stem cell proliferation.
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.

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