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Using a lineage tracing model, it is demonstrated that adult murine hematopoiesis is contingent on the continuous output from HSCs, with quantitative contributions that are dependent on lineage-type and age.

A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection.

Zebrafish pigment cell progenitors are a heterogeneous class of adult tissue-resident cells which reiterate developmental signaling during melanocyte regeneration.

Spatial variations of transcription factor expression regulate the choice of progenitors to stay in their niche or to migrate into neural and mesodermal tissues.

Cartilage cells transition through a proliferative intermediate to give rise to bone and marrow fat cells in long bones.

During early cortical development, microRNA-128 regulates the homeostasis of neural stem cells by targeting PCM1, a protein that is critical for cell division.

Using multiple genetic reporter system in human pluripotent stem cells, a transcriptional database for human early myogenesis has been established.

5-Hydroxymethylcytosine-mediated active DNA demethylation occurs in postmitotic neurons, and is required for their terminal differentiation and function.

HCAR1 knockout mice are unable to initiate brain tissue repair after a hypoxic-ischemic injury.