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    1. Neuroscience

    Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure

    Rafael Renteria, Christian Cazares ... Christina M Gremel
    Chronic alcohol exposure results in a long-lasting, enhanced endocannabinoid signalling at orbitostriatal synapses that is expressed in a projection-, synapse-, and behaviorally computation-specific manner.
    1. Cell Biology
    2. Evolutionary Biology

    Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

    Matteo Fumagalli, Stephane M Camus ... Frances M Brodsky
    Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.
    1. Neuroscience

    A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

    Yi Bessie Liu, Ambika Tewari ... Kathleen J Sweadner
    A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
    1. Neuroscience

    Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex

    J Daniel Obray, Erik T Wilkes ... L Judson Chandler
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Medicine
    2. Neuroscience

    Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia

    Srdjan Sumarac, Kiah A Spencer ... Luka Milosevic
    The hypo- versus hyperkinetic nature of Parkinson’s disease and dystonia, respectively, may be reflected by differences in disease-specific spiketrain dynamics and striato-pallidal synaptic plasticity.
    1. Medicine
    2. Neuroscience

    Citizen Science: Asking questions of psychedelic microdosing

    Lindsay P Cameron
    A citizen science approach to research has shown that the improvements in mood and cognition associated with psychedelic microdosing are likely due to a placebo effect.
    Version of Record
    Insight
    1. Neuroscience

    Frequency-specific neural signatures of perceptual content and perceptual stability

    Richard Hardstone, Matthew W Flounders ... Biyu J He
    While perceptual content is encoded in non-oscillatory activity in the slow cortical potential (<5 Hz) range, perceptual stability is predominantly influenced by the amplitude fluctuations of alpha (~10 Hz) and beta (~20 Hz) brain oscillations.
    1. Neuroscience

    Multi-dimensional oscillatory activity of mouse GnRH neurons in vivo

    Su Young Han, Shel-Hwa Yeo ... Allan E Herbison
    The gonadotropin-releasing hormone (GnRH) neurons controlling fertility exhibit abrupt increases in activity to generate luteinizing hormone (LH) pulses and a sustained oscillatory pattern of activity to generate the LH surge.
    1. Neuroscience

    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

    Qin Wang, Huaxun Fan ... Kai Zhang
    Precise spatiotemporal optogenetic activation of ERK and AKT signaling pathways reveals neural repair mechanisms of the peripheral and central nervous systems in live Drosophila larvae.