22 results found
    1. Chromosomes and Gene Expression

    Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

    Gang Wu et al.
    RNA profiles from lungs of mice exposed to intermittent hypoxia shared similarity with gene expression changes in human lung from patients with pulmonary diseases, including pulmonary hypertension, COPD, and asthma.
    1. Medicine

    Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis

    Qiankun Bao et al.
    Targeting STAT3 provides a potential therapeutic strategy for obstructive sleep apnea-related fibrotic heart disease mediated by TSP1.
    1. Neuroscience

    Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans

    Lasse Christiansen et al.
    Acute intermittent hypoxia is a noninvasive approach that enhances corticospinal function in humans, likely through alterations in corticospinal-motoneuronal synaptic transmission.
    1. Neuroscience

    One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

    Austin D Hocker et al.
    A single neonatal inflammatory event induces long-term impairments in two forms of adult respiratory motor plasticity, an important aspect of the control of breathing for compensation after injury or disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Mixed-mode oscillations and population bursting in the pre-Bötzinger complex

    Bartholomew J Bacak et al.
    Computational modeling reveals the mechanisms by which a diverse group of neurons in the brainstem generates rhythmic breathing in mammals.
    1. Neuroscience

    Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells

    Christina Chatzi et al.
    Neural progenitors reside in relative low oxygen in the subgranular zone (SGZ), and the higher tissue oxygen levels that these cells must face as they migrate away from the hypoxic areas and differentiate appear to cause oxidative damage and an early phase of cell death.
    1. Neuroscience

    Interactions between respiratory oscillators in adult rats

    Robert TR Huckstepp et al.
    Active expiration in anesthetized rats is driven by the lateral parafacial region, but requires an additional form of excitation from another source.
    1. Computational and Systems Biology
    2. Neuroscience

    Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

    Amin Haghani et al.
    Transcriptome analysis of mouse brain revealed that the APOE4 allele and sex can alter air pollution neurotoxicity in adults.
    1. Neuroscience

    Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

    Ashley L Kalinski et al.
    In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

    Michelle C Ward et al.
    Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.

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