The transcriptomic and epigenetic landscapes of developing human articular and growth plate cartilage reveal putative gene regulatory networks governing lineage commitment and tissue homeostasis.

Fish schools showed an U-shaped metabolism-speed curve and reduced the energy use per tail beat up to 56% at high swimming speeds compared to solitary fish.

Opioids cause hyperpolarization and pre-synaptic suppression among a subset of preBötzinger Complex neurons to impair respiratory rhythmogenesis.

The specific metabolic pathways that increase neuron regeneration in ogt-1 mutant C. elegans following in vivo laser axotomy, highlighting the potential power for such metabolic targets in the treatment of neuronal injury.

Opioids stop breathing during overdose by silencing two small brain sites, with just 140 neurons in the breathing rhythm generator exerting the key effect.

A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8⁺ T cell function, anti-tumor immunity, and immunotherapy responsiveness.

The tyrosine degradation pathway reprogramming connects mitochondrial dysfunction, aging, and production of tyrosine-derived neuromediators that can be targeted with an FDA-approved drug, Tigecycline.

A combination of bioinformatics, protein biochemistry, and X-ray crystal structures reveals new bacterial proteins that are capable of binding to sterols.

Hypothalamic stress effector neurons rapidly change activity patterns via recurrent inhibition, representing state-dependent activity switch between baseline and elevated stress levels.

Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.