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    1. Genetics and Genomics
    2. Neuroscience

    Cell non-autonomous regulation of health and longevity

    Hillary A Miller et al.
    Modulation of the aging process through cell signaling represents a recent and exciting area of study with the potential for development of therapeutics to extend human health.
    1. Neuroscience

    VEGF signaling regulates the fate of obstructed capillaries in mouse cortex

    Patrick Reeson et al.
    Mapping the fate of clogged brain capillaries reveals that VEGF signaling plays a critical role in dictating whether capillaries regain blood flow and persist or are pruned from the vascular tree.
    1. Neuroscience
    2. Medicine

    Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury

    Shawniqua T Williams et al.
    The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.
    1. Neuroscience

    Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network

    Nathan A Baertsch et al.
    Opioids cause hyperpolarization and pre-synaptic suppression among a subset of preBötzinger Complex neurons to impair respiratory rhythmogenesis.
    1. Genetics and Genomics

    Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

    Andrey A Parkhitko et al.
    The tyrosine degradation pathway reprogramming connects mitochondrial dysfunction, aging, and production of tyrosine-derived neuromediators that can be targeted with an FDA-approved drug, Tigecycline.
    1. Cancer Biology
    2. Immunology and Inflammation

    The effects of age and systemic metabolism on anti-tumor T cell responses

    Jefte M Drijvers et al.
    A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8+ T cell function, anti-tumor immunity, and immunotherapy responsiveness.
    1. Neuroscience

    PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

    Clément Menuet et al.
    The PreBötzinger complex, which contains neurons that are the kernel for inspiratory rhythm generation, also contains sympathoexcitatory and parasympathoinhibitory neurons that drive respiratory-phase oscillations in blood pressure and heart rate.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias

    Bradford M Stubenhaus et al.
    Physiological porphyrin biosynthesis causes photosensitivity in fasted planarians, providing an experimentally tractable animal model of acute porphyrias.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

    Jenny I Aguilar et al.
    A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.
    1. Medicine

    Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise

    Matthew Hancock et al.
    Cardiomyocyte Nox4 is a crucial physiological mediator of Nrf2 activation during acute exercise, triggering an adaptive response that preserves redox balance, mitochondrial and cardiac function to support normal physical exercise.