318 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

    Priyanka D Abeyrathne et al.
    An ensemble of cryo-EM structures reveals how eukaryotic elongation factor 2 positions the first codon of a viral mRNA for translation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling

    Zane A Jaafar et al.
    The hepatitis C virus IRES binds and remodels preassembled eukaryotic translation preinitiation complexes, using specific initiation factor protein within a "bacterial-like" mode of initiation that can function in both stressed and unstressed cells.
    1. Biochemistry and Chemical Biology

    Kinetics of initiating polypeptide elongation in an IRES-dependent system

    Haibo Zhang et al.
    The retarding effect of a ribosome-bound internal ribosome entry site on eukaryotic protein synthesis is largely overcome following translocation of tripeptidyl-tRNA.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of ribosome recruitment and translocation by type IV IRES

    Jason Murray et al.
    A Internal Ribosomal Entry Site RNA has been visualised by high resolution cryoEM, trapped in the ribosome in an intermediate state of translocation.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Neuroscience

    Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure

    Aitak Farzi et al.
    CART exerts differential metabolic effects in response to activation of neurons of the Arc, where CART suppresses energy expenditure, while it enforces the reward characteristics of the LHA.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-protein detection in crowded molecular environments in cryo-EM images

    J Peter Rickgauer et al.
    High-resolution template matching makes small, densely embedded proteins detectable.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

    Rachel W Anantha et al.
    Systematic analyses of natural variants and artificial mutants establish functional landscapes of BRCA1 for homology-directed repair (HDR) and therapy resistance and identify the BRCA1-PALB2 interaction as a key control point for HDR pathway choice.

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