7,195 results found
    1. Human Biology and Medicine
    2. Neuroscience

    Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors

    Joshua S Talboom et al.
    An internet-based cohort study of paired associate learning shows that a first-degree family history of dementia is associated with lowered performance, an effect modified by apolipoprotein E genotype and diabetes.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A twist defect mechanism for ATP-dependent translocation of nucleosomal DNA

    Jessica Winger et al.
    Based on its nucleotide-bound state, the Chd1 chromatin remodeler can locally alter DNA twist on the nucleosome, which either pulls in or expels ~1 bp of DNA at the internal SHL2 binding site.
    1. Neuroscience

    A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal

    Ian D Blum et al.
    An internal clock based on brain levels of dopamine works with the circadian clock to maintain daily patterns of alertness and activity, and may be implicated in the altered behavioral patterns seen in schizophrenia and bipolar disorder.
    1. Structural Biology and Molecular Biophysics

    Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

    Ashok Sekhar et al.
    NMR-based flux measurements show that both bacterial and human Hsp70 chaperones interact with helical, as well as sheet substrates predominantly through a conformational selection mechanism.
    1. Neuroscience

    Basal ganglia output reflects internally-specified movements

    Mario J Lintz, Gidon Felsen
    The basal ganglia may preferentially influence movements based on internal goals rather than those guided by external stimuli.
  1. Intellectual property for everyone: an interview with Monica Alandete-Saez

    For many years plant scientist Monica Alandete-Saez assumed that she would spend her whole career in academic research, but a desire to interact more directly with other sectors of society led her to explore other options. She now works for PIPRA, a small not-for-profit technology commercialization organization based on the campus of the University of California Davis.
  2. Plain-language Summaries of Research: An inside guide to eLife digests

    Stuart RF King et al.
    After summarizing over 2,400 articles in plain language, the eLife Features team shares what it has learnt about writing and editing for a broad audience.

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