Anterior insular cortex activity predicts how well we attend to our bodily signals, while lesions to this brain region disrupt this ability.

People who have attempted suicide exhibit blunted sensory processing during breathing and pain perturbations, as well as lower heartbeat perception accuracy and reduced mid/posterior insula activity during interoceptive attention.

Pre-verbal infants demonstrate an implicit sensitivity to interoceptive sensations, which fluctuates spontaneously during emotional processing and guides audiovisual preferences in the environment.

Asymmetric activation of the dysgranular mid-insula during interoceptive processing contributes to disrupted bodily awareness in individuals with anxiety, depression, and eating disorders.

Training attention-mindfulness, emotion-motivational, and social cognitive skills over the course of 3 months alters brain functional and microstructural organization as a function of training content.

A laboratory experiment provides the first evidence that framing a sham treatment as personalised to one's genetics and physiology increases its placebo effect on pain.

Lesion analyses in right hemisphere stroke patients reveal the crucial role of the right anterior and posterior insula in the perception of affective touch.

Changes in physiological arousal – as revealed by pupil dilation and heart rate – shape our confidence in decisions about uncertain perceptual information.

Neural correlates of somatosensory target detection are restricted to secondary somatosensory cortex, whereas activity in insular, cingulate, and motor regions reflects stimulus uncertainty and overt reports.