5,198 results found
    1. Genetics and Genomics

    An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

    Jun Zou et al.
    The newly discovered Titin internal promoter may explain why the severity of dilated cardiomyopathy in patients with truncating mutations in Titin varies dramatically depending on position of the mutation.
    1. Neuroscience

    Striatal dynamics explain duration judgments

    Thiago S Gouvêa et al.
    Neurons in the rat striatum respond preferentially to long or short time intervals, enabling the animal to track the passage of time.
    1. Neuroscience

    Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing

    Jun Kunimatsu et al.
    Neuronal activity in the striatum keeps track of elapsed time during the time production task while that in the cerebellum correlates with stochastic variation of self-timing in the range of several hundreds of milliseconds.
    1. Neuroscience

    Entrainment and maintenance of an internal metronome in supplementary motor area

    Jaime Cadena-Valencia et al.
    Temporal rhythms are encoded in the supplementary motor area by firing rate oscillations and rhythmic bursts of gamma-band LFP activity.
    1. Neuroscience

    Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways

    Konstantin I Bakhurin et al.
    Direct and indirect pathways in the basal ganglia have opposing effects not only on action performance but also on internal timing of expected reward delivery.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Biophysical clocks face a trade-off between internal and external noise resistance

    Weerapat Pittayakanchit et al.
    Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.
    1. Evolutionary Biology
    2. Neuroscience

    Recalibrating timing behavior via expected covariance between temporal cues

    Benjamin J De Corte et al.
    Rats act as if they expect that the delays associated with temporal cues will covary due to a common causal factor.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Neuroscience

    Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

    Christian M Gallardo et al.
    For mice, knowing when it is time to feed is dependent on the neurotransmitter dopamine and the D1R receptor of neurons in the dorsal striatum.
    1. Neuroscience

    The human cerebellum is essential for modulating perceptual sensitivity based on temporal expectations

    Assaf Breska, Richard B Ivry
    Cerebellar degeneration disrupts the use of interval-based temporal cues, but not rhythmic cues, to proactively modulate perceptual sensitivity, implicating the cerebellum in temporal control of visual attention.

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