852 results found
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang et al.
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Cell Biology
    2. Developmental Biology

    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

    Qian Yu et al.
    Corneal aging is regulated by the NF-κB-retinoic acid pathway and can be delayed by retinoic acid administration.
    1. Cancer Biology

    Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

    Andrea Sacchetti et al.
    Colon cancer cells disseminate and colonize distant organ sites along the invasion-metastasis cascade by transiently activating intermediate epithelial to mesenchymal transition states through distinct transcriptional trajectories.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

    Yu-Xuan Lu et al.
    Modulation of histone levels in gut enterocytes by rapamycin treatment alters chromatin organisation and induces intestinal autophagy through transcriptional regulation to prevent age-related decline in the intestine and extend lifespan.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    TRPM channels mediate learned pathogen avoidance following intestinal distention

    Adam Filipowicz et al.
    Behavioral assays using Caenorhabditis elegans show that a learned pathogen avoidance following intestinal distention requires specific chemosensory neurons and TRPM channels in the intestine and excretory cell.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation

    Elizabeth R Hughes et al.
    Bioinformatics analyses and experiments in mouse models reveal how Escherichia coli accesses the molecular hydrogen pool to boost colonization during acute colitis.
    1. Cell Biology
    2. Immunology and Inflammation

    Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

    Timurs Maculins et al.
    Multiplexed mass spectrometry shows how the autophagy gene Atg16l1 regulates macrophage innate immunity against intracellular bacterial pathogens by modulating basal oxidative stress responses.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

    Erin J Golden et al.
    Taste cell renewal begins at birth and is promoted by sonic hedgehog that alters the expression of regulators of cell migration and adhesion that may allow entry of new cells into buds.
    1. Epidemiology and Global Health
    2. Medicine

    An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

    Torsten Dahlén et al.
    The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.

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