260 results found
    1. Developmental Biology

    The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

    Ellen N Elliott et al.
    The maintenance methyltransferase Dnmt1 and the de novo methyltransferase Dnmt3b cooperate to maintain DNA methylation and genomic stability in the adult intestinal epithelium.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill et al.
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Cell Biology

    Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila

    Jung-Kun Wen et al.
    Atg9 inhibits TOR signaling to regulate cell growth and tissue homeostasis in Drosophila adult midgut.
    1. Microbiology and Infectious Disease

    Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

    Siyuan Ding et al.
    Rotavirus infection induces phosphorylation and proteasomal degradation of MAVS to suppress host antiviral interferon signaling.
    1. Stem Cells and Regenerative Medicine

    Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

    Aiguo Tian, Jin Jiang
    The niche signal that ensures stem cells self-renew appropriately has been identified in the midgut of Drosophila.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Claudin-2-dependent paracellular channels are dynamically gated

    Christopher R Weber et al.
    Paracellular, trans-tight junction channels, which communicate between two extracellular compartments without crossing the plasma membrane, are a new class of ion channel with unitary behaviors similar to traditional transmembrane channels.
    1. Cancer Biology
    2. Cell Biology

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis

    Lukas Franz Mager et al.
    ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
    1. Cell Biology
    2. Developmental Biology

    Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia

    Kara L McKinley et al.
    The process of cytokinesis can allow cell lineages to intermix in mammalian epithelia, and cellular aspect ratio is a critical modulator of this behavior.
    1. Developmental Biology

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

    Tobias Reiff et al.
    A hormone released after mating acts directly on adult intestinal progenitors and differentiated epithelial cells in Drosophila to change their homeostatic setpoint and maximise fecundity.
    1. Cell Biology
    2. Developmental Biology

    Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

    Preetish Kadur Lakshminarasimha Murthy et al.
    Fringe proteins regulate Notch pathway differentially in the stem cell zone and progenitor compartment of the mouse intestinal epithelium to promote homeostasis.

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