639 results found
    1. Stem Cells and Regenerative Medicine

    Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

    Yuhua Tian et al.
    miR-31 drives proliferation of intestinal stem cells, and protects intestinal stem cells against apoptosis both during homeostasis and regeneration in response to ionizing radiation injury, and promotes intestinal tumorigenesis through regulation of multiple signaling pathways.
    1. Stem Cells and Regenerative Medicine

    Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

    Aiguo Tian, Jin Jiang
    The niche signal that ensures stem cells self-renew appropriately has been identified in the midgut of Drosophila.
    1. Stem Cells and Regenerative Medicine

    Cohesin controls intestinal stem cell identity by maintaining association of Escargot with target promoters

    Aliaksandr Khaminets et al.
    Cohesin-regulated 3D genome conformation controls activity of transcription factor Escargot in intestinal stem cells, prevents premature differentiation into enterocytes and maintains intestinal homeostasis.
    1. Cell Biology
    2. Developmental Biology

    Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

    Preetish Kadur Lakshminarasimha Murthy et al.
    Fringe proteins regulate Notch pathway differentially in the stem cell zone and progenitor compartment of the mouse intestinal epithelium to promote homeostasis.
    1. Stem Cells and Regenerative Medicine

    Physiological and stem cell compartmentalization within the Drosophila midgut

    Alexis Marianes, Allan C Spradling
    The intestine contains distinct subregions specialized for digestion along its anterior-posterior axis, and the stem cells that constantly renew these subregions are not interchangeable.
    1. Stem Cells and Regenerative Medicine

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin et al.
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
    1. Developmental Biology

    Organ Plasticity: Paying the costs of reproduction

    Thomas Flatt
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    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Vladimir Chubanov et al.
    Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis

    Jun Chen et al.
    A newly discovered feedback amplification loop between stem cells and their immediate daughter progenitor cells drives epithelial regeneration and tumor development.
    1. Developmental Biology

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

    Tobias Reiff et al.
    A hormone released after mating acts directly on adult intestinal progenitors and differentiated epithelial cells in Drosophila to change their homeostatic setpoint and maximise fecundity.

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