BoNT intoxication of neurons is revisited using a genome-wide siRNA screen and organelle-specific reporters, suggesting a mechanism of translocation to the cytosol fundamentally different than previously proposed.

Cholera intoxication of human colonic epithelial cells is dependent on recognition of protein glycosylation and fucosylation, not exclusively on ganglioside recognition as proposed previously.

Interbacterial interactions can promote mutagenesis, and possibly adaptation, when intoxicated cells survive exposure to type VI secretion-delivered DNA deaminase toxins.

Δ⁹-Tetrahydrocannabinol impairs motor coordination in mice by inhibiting autophagy in the striatonigral pathway, thus defining a new conceptual view of how cannabis acts in the brain.

Bacterial location quantifications highlights how Drosophila melanogaster larvae discriminate bacteria to isolate and later eliminate pathogens in the anterior midgut through coordinated mechanisms involving reactive oxygen species (ROS) and antimicrobial peptides (AMPs).

Alcohol modifies dopaminergic microcircuits required for acquisition and expression of sensory memories in Drosophila resulting in a shift in behavioral response from malleable to inflexible.

Pseudomonas aeruginosa defends against interbacterial antagonism through the coordinated expression of previously uncharacterized pathways that grant threat-specific protection.

The spiking activity of the subthalamic nucleus, rather than the activity of striatal projection neurons, orchestrates basal ganglia downstream activity and output commands in health and Parkinson’s disease.

Diverse LXG toxins delivered by the Esx pathway function as mediators of contact-dependent interbacterial antagonism within and between Gram-positive bacterial species.

Output neurons in the mushroom body of the fruit fly brain encode the positive or negative survival value of stimuli, enabling insects to choose adaptive approach and avoidance behaviors through associative learning.