1,997 results found
    1. Cell Biology

    Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

    Thomas M Rawlings, Komal Makwana ... Emma S Lucas
    The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.
    1. Cancer Biology
    2. Immunology and Inflammation

    Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

    Ngoc Lan Tran, Lorena Maria Ferreira ... Giovanni Sitia
    Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.
    1. Structural Biology and Molecular Biophysics

    Identification of electroporation sites in the complex lipid organization of the plasma membrane

    Lea Rems, Xinru Tang ... Lucie Delemotte
    Advanced data analysis of molecular dynamics simulations of complex lipid membranes provides a quantitative and predictive model of the molecular features that control electroporation.
    1. Developmental Biology

    Inhibition of the Notch signal transducer CSL by Pkc53E-mediated phosphorylation to fend off parasitic immune challenge in Drosophila

    Sebastian Deichsel, Lisa Frankenreiter ... Anja C Nagel
    Pkc53E kinase-mediated downregulation of CSL/Su(H) activity is a direct molecular response to parasitoid wasp infestation in Drosophila, allowing the differentiation of encapsulation-active lamellocytes, thereby ensuring an appropriate immune defense.
    1. Neuroscience

    Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

    Sahana Sitaraman, Gnaneshwar Yadav ... Vatsala Thirumalai
    A protein that is a building block of intercellular bridges between neurons promotes their ability to grow dendrites and make synapses.
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin, Erin Nicole Sanders ... Lucy Erin O'Brien
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.
    1. Neuroscience

    Homeostatic reinforcement learning for integrating reward collection and physiological stability

    Mehdi Keramati, Boris Gutkin
    A mathematical model built around the assumption that the desire to maintain internal homeostasis drives the behavior of animals, by affecting their learning processes, can explain many real-world behaviors, including some that might otherwise appear irrational.
    1. Cell Biology
    2. Developmental Biology

    Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin

    Damian E Dalle Nogare, Naveen Natesh ... Ajay B Chitnis
    Epithelial cells utilize a covering sheath of motile cells to migrate in confinement.
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.

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