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    1. Biophysics and Structural Biology
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    1. Neuroscience

    Chronic pain induces generalized enhancement of aversion

    Qiaosheng Zhang et al.
    Chronic pain distorts intensity coding in the anterior cingulate cortex to give rise to generalized anatomically nonspecific enhancement in pain aversion.
    1. Biophysics and Structural Biology
    2. Neuroscience

    A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

    Matthias Lübbert et al.
    A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.
    1. Neuroscience

    Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

    Jordan G McCall et al.
    Selective activation of locus coeruleus noradrenergic terminals drives anxiety-like behaviors through activation of β-adrenergic receptors in the basolateral amygdala.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Physical limits of flow sensing in the left-right organizer

    Rita R Ferreira et al.
    Large-scale in vivo imaging of the zebrafish left-right organizer (Kupffer's vesicle) combined with fluid dynamics calculations allows to quantitatively test the possible flow detection mechanisms and supports the flow transport of chemical signals as the mechanism of side determination.
    1. Cell Biology
    2. Neuroscience

    Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses

    Laurent Guillaud et al.
    In central synapses, the mobility and supply of synaptic vesicles are determined by two independent biological factors: the morphological and structural organization of nerve terminals and the molecular signature of vesicles.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto et al.
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng et al.
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Investigating molecular crowding within nuclear pores using polarization-PALM

    Guo Fu et al.
    The super-resolution fluorescence microscopy approach polarization PALM (p-PALM) reveals that macromolecular crowding and inhomogeneity within nuclear pores generate a structurally and dynamically complex permeability barrier.
    1. Cell Biology

    An adaptation of astronomical image processing enables characterization and functional 3D mapping of individual sites of excitation-contraction coupling in rat cardiac muscle

    Qinghai Tian et al.
    The fusion of astronomy and cellular cardiology reveals the 3D arrangement and the firing reliability of active excitation-contraction coupling sites in beating cardiac myocytes.