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In vivo analysis of endogenously tagged Ca²⁺ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.

Male-type aggressive and courtship behaviors of the fruit flies are differentially specified by two sex-determining genes, providing a substrate for the evolution to sculpt these two behaviors independently.

Cardiovascular disease, the top cause of diabetic deaths, progresses via vascular endothelial dysfunction, with circHMGCS1 and miR4521 highlighted as potential markers for the development of this condition.

A new biophysical model enables the reconciliation of ultrastructural and tissue level measurements on parameters affecting intercellular communication, and provides novel functional insight into experimental findings.

A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.

SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.

Direct measurements of trafficking kinetics between organelles of the secretory pathway suggest that lipid-driven membrane domains laterally sort proteins during membrane traffic.

Slow presynaptic depression in olfactory receptor neurons rescales combinatorial odor representations in postsynaptic neurons and mediates the encoding of stimulus mean and variance.

Chronic dysregulation of matrix-metalloproteinase 9, which is associated with some neurodevelopmental disorders, leads to local hyperconnectivity in the developing brain, resulting in altered sensory processing and increased seizure susceptibility.

Optimised genome editing in P. knowlesi enables transgenic expression of a lead P. vivax vaccine candidate, revealing roles in host cell tropisms and providing tools for scalable vaccine efficacy testing.