48 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis

    Michael Taschner et al.
    CRISPR/Cas knockout of intraflagellar transport protein 80 shows that this subunit is absolutely required for ciliogenesis, and biophysical studies reveal that this protein may dimerize the intraflagellar transport complex.
    1. Cell Biology

    Intraflagellar transport drives flagellar surface motility

    Sheng Min Shih et al.
    The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.
    1. Cell Biology

    TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

    Hiroaki Ishikawa et al.
    Loss of one protein from the intraflagellar transport complex leads to a defect in import of a specific sub-set of proteins into the flagellum.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dynamics of the IFT machinery at the ciliary tip

    Alexander Chien et al.
    During intraflagellar transport (IFT), kinesin-II dissociates from IFT trains at the flagellar tip and its diffusion in flagella serves as a negative feedback mechanism that facilitates flagellar length control in Chlamydomonas.
    1. Cell Biology

    Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

    Muqing Cao et al.
    During cilium-generated signaling, ciliary membrane protein trafficking is unidirectional and ciliary membrane protein composition is regulated through action in the cytoplasm of the retrograde intraflagelllar transport (IFT) motor and shedding of ciliary ectosomes.
    1. Cell Biology

    The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

    Diego Huet et al.
    A small GTPase within the flagellum can participate in the control of transport from the base to the tip of the flagellum, and back again.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar Transport: Moving proteins along in the cilium

    Narcis Adrian Petriman, Esben Lorentzen
    The structures of the bovine and human BBSome reveal that a conformational change is required to recruit the complex to the ciliary membrane.
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Intraflagellar transport: Trainspotting in a cilium

    Dhivya Kumar, Stephen M King
    A new imaging technique sheds light on how cilia regulate their length and growth.
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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Length-dependent disassembly maintains four different flagellar lengths in Giardia

    Shane G McInally et al.
    Giardia, a multi-ciliated parasitic protist, maintains four different flagellar lengths by balancing flagellar length-independent IFT-mediated assembly with length-dependent kinesin-13 mediated disassembly.

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