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    1. Neuroscience

    Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

    Xunde Xian et al.
    Lowering endosomal pH through inhibition of sodium-hydrogen exchanger 6 corrects the ApoE4-induced Reelin resistance and restores neuronal glutamate receptor trafficking.
    1. Neuroscience

    Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

    Virginie Mansuy-Aubert et al.
    In sensory neurons, the receptors LXRα and LXRβ sense dietary-derived molecules to regulate whole body energy expenditure, and present a possible target for new anti-obesity agents.
    1. Neuroscience
    2. Physics of Living Systems

    Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback

    Joanne C Gordon et al.
    Running guinea fowl maintain stable running after loss of the stretch reflex in a major ankle extensor muscle, by increasing feedforward muscle activation to maintain ankle stiffness and work output.
    1. Neuroscience

    Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells

    Justyna Ulanska-Poutanen et al.
    Distinctive microenvironments within demyelinated white matter determine fate decisions of adult oligodendrocyte progenitor cells.
    1. Neuroscience

    LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

    Daniela Puzzo et al.
    Oligomeric Amyloid-β and Tau, two proteins involved in Alzheimer's disease pathogenesis, require Amyloid Precursor Protein to enter neurons and exert their detrimental effect on synaptic plasticity and memory.
    1. Neuroscience

    Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation

    Rosa Maria Sanchez Panchuelo et al.
    The combination of intraneural microstimulation and 7T fMRI makes it possible to bridge the gap between first-order mechanoreceptive afferent input codes and their spatial, dynamic and perceptual representations in human cortex.
    1. Immunology and Inflammation
    2. Neuroscience

    Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury

    David Tweedie et al.
    Protein changes in cerebral cortex following a mild traumatic brain injury (mTBI) identified herein will help in the development of monitoring and response biomarkers that may translate to clinical mTBI.
    1. Neuroscience

    Computational Neuroscience: Finding patterns in cortical responses

    Alessandro Sanzeni, Mark H Histed
    Simulations predict a paradoxical effect that should be revealed by patterned stimulation of the cortex.
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

    J Robert Lane et al.
    The occupation of a sub-pocket near the Na+-binding site in D2R by the Na+-insensitive antagonists is the structural basis for their greater inverse agonism than that of the Na+-sensitive ligands.
    1. Cell Biology
    2. Immunology and Inflammation

    Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

    Maria-Bernadette Madel et al.
    Osteoclasts emerging in inflammation are heterogeneous and encompass a strongly inflammatory subset with a high resorbing activity and an immune suppressive subset that are able to control each other.