84 results found
    1. Cancer Biology
    2. Immunology and Inflammation

    Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy

    Shuhong Qi et al.
    Tregs form an "immunosuppressive ring" around solid tumors that is broken down during adoptive cell therapy and cyclophosphamide combination immunotherapy.
    1. Cell Biology
    2. Computational and Systems Biology

    Removing physiological motion from intravital and clinical functional imaging data

    Sean C Warren et al.
    Image-based motion correction enables the use of fluorescence lifetime and other functional imaging modalities in an intravital and clinical context in the presence of physiological motion.
    1. Immunology and Inflammation

    Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

    Carolin Ulbricht et al.
    Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
    1. Immunology and Inflammation

    Capturing change in clonal composition amongst single mouse germinal centers

    Daniel J Firl et al.
    Repeated interrogation of single germinal centers in vivo reveals a more fluid landscape than expected and unlocks new lines of investigation.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Label-free imaging of immune cell dynamics in the living retina using adaptive optics

    Aby Joseph et al.
    Immune cell motility and vascular response are imaged in vivo and label free in the CNS for the first time, using high-resolution phase-contrast adaptive optics retinal imaging.
    1. Immunology and Inflammation

    Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

    Olga Barreiro et al.
    A new type of skin perivascular macrophages with extramedullary origin, access to blood and exclusive anti-inflammatory reparative properties has been characterized.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

    Chung Park, John H Kehrl
    Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.
    1. Neuroscience

    Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses

    Yulia Akbergenova et al.
    Active zone release probability is correlated with calcium channel density and calcium influx at single release sites, with release strength increasing in an activity-dependent manner during synapse maturation.
    1. Microbiology and Infectious Disease

    Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

    Christine S Hopp et al.
    Malaria parasites enter the host via the skin, where they are inoculated by an infected mosquito as it probes for blood: the inoculation site is a bottleneck for the parasite and the only time when the parasite is extracellular for more than a few minutes, thus possibly presenting the best opportunity for antibody-mediated inhibition of infection.
    1. Immunology and Inflammation

    The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

    Chung Park et al.
    Lymph node gp120 specific B cells extract locally injected HIV-1 gp120 from SIGN-R1 positive macrophages that line the subcapsular sinus overlying the lymph node interfollicular channels.

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