1,131 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

    Mikel Garcia-Marcos
    Heterotrimeric G-proteins can be switched on not only by G-protein-coupled receptors but also by cytoplasmic proteins, resulting in different signaling mechanisms in cells depending on the specific type of activator.
    1. Biochemistry and Chemical Biology

    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

    Vidyasiri Vemulapalli et al.
    Monitoring SHP2 phosphoproteome dynamics identifies new substrate sites and sites protected from dephosphorylation by its SH2 domains, highlighting distinct scaffolding and catalytic activities in effecting a transmembrane signaling response.
    1. Structural Biology and Molecular Biophysics

    Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor

    John R Strikwerda, Steven M Sine
    Mutating a highly conserved intramembrane salt bridge unmasks structural and functional coupling between channel gating and ion permeation in the muscle nicotinic receptor.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis

    Arne Sahm et al.
    The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.
    1. Neuroscience

    Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

    Roberto de Filippo et al.
    Somatostatin interneurons are novel mediators of serotonergic modulation in entorhinal cortex via activation of 5-HT2A receptors, a receptor involved in the etiology of different psychiatric disorders.
    1. Chromosomes and Gene Expression

    Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition

    Emily Hsu et al.
    CBP/p300 acetylation of histone H3 at promoters and enhancers stimulates transcriptional elongation through recruitment of the super-elongation complex and BRD4.
    1. Neuroscience

    All-trans retinoic acid induces synaptic plasticity in human cortical neurons

    Maximilian Lenz et al.
    The vitamin A derivative, all-trans retinoic acid, induces protein-synthesis-dependent synaptic plasticity in the human brain.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

    Sabrina Vullo et al.
    Analysis of conformational changes indicates that activation of acid-sensing ion channels involves protonation of diverse extracellular sites and interaction of interdomain loops with the upper ends of transmembrane helices.
    1. Developmental Biology
    2. Neuroscience

    The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli

    Nobuko Inoue et al.
    The critical period in the mouse olfactory system is defined by activity-dependent synapse formation induced by Semaphorin7A/PlexinC1 signaling in the neonatal glomeruli.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Eitan Lerner et al.
    A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.

Refine your results by:

Type
Research categories