In vivo and ex vivo analysis of the activity-regulated gene Rem2 in the mouse visual system sheds new light on the contribution of intrinsic excitability in circuit plasticity.
In addition to its classic role in synaptic function and plasticity, macroautophagy regulates neuronal intrinsic excitability via degradation of acetylated Kir2 channels to control neurotransmission.
Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
The regulation of Phf6 by miR-128 is a developmental timing mechanism that influences cortical lamination, neuronal morphology and intrinsic excitability.
Synaptic scaling maintains motor output from the respiratory network of bullfrogs after months of inactivity in the winter, providing evidence for homeostatic plasticity in response to large ecologically relevant perturbations in neuronal activity.
Activation of the same glutamate receptor in the lateral amygdala gives rise to distinct effects on specific versus indiscriminate fear by modulating intrinsic excitability and synaptic plasticity.
Fluorescence lifetime imaging microscopy, paired with fluorescent, voltage-sensitive dyes, provides a method for measuring and quantifying membrane potentials of living cells.
Deep brain calcium imaging reveals the abnormal neuronal activity patterns of the amygdala GABAergic neurons in an animal model of human sleep disorder narcolepsy.
The dorsal raphe nucleus contains transcriptionally diverse cell classes that include subtypes of serotonergic neurons with distinct molecular and anatomical signatures.
