332 results found
    1. Neuroscience

    Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits

    Anna R Moore et al.
    In vivo and ex vivo analysis of the activity-regulated gene Rem2 in the mouse visual system sheds new light on the contribution of intrinsic excitability in circuit plasticity.
    1. Cell Biology
    2. Neuroscience

    Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy

    Ori J Lieberman et al.
    In addition to its classic role in synaptic function and plasticity, macroautophagy regulates neuronal intrinsic excitability via degradation of acetylated Kir2 channels to control neurotransmission.
    1. Neuroscience

    Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells

    Ramesh Chittajallu et al.
    Similar to their mouse counterparts, human neurogliaform cells that comprise a specialized from of inhibitory neuron, possess the ability to modulate their intrinsic excitability in response to ongoing network activity.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Cell Biology
    2. Developmental Biology

    miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

    Eleonora Franzoni et al.
    The regulation of Phf6 by miR-128 is a developmental timing mechanism that influences cortical lamination, neuronal morphology and intrinsic excitability.
    1. Neuroscience

    Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory

    David Levitan et al.
    Stk11 and Fos expression plays an important role in CTA long-term memory formation by modulating the intrinsic excitability of BLApn.
    1. Neuroscience

    Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity

    Joseph M Santin et al.
    Synaptic scaling maintains motor output from the respiratory network of bullfrogs after months of inactivity in the winter, providing evidence for homeostatic plasticity in response to large ecologically relevant perturbations in neuronal activity.
    1. Neuroscience

    Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome

    Javier Zorrilla de San Martin et al.
    Distinct intrinsic excitability and synaptic dysfunctions in specific cortical inhibitory circuits lead to abnormal network activity in a mouse model of Down syndrome.
    1. Neuroscience

    Activation of the same mGluR5 receptors in the amygdala causes divergent effects on specific versus indiscriminate fear

    Mohammed Mostafizur Rahman et al.
    Activation of the same glutamate receptor in the lateral amygdala gives rise to distinct effects on specific versus indiscriminate fear by modulating intrinsic excitability and synaptic plasticity.
    1. Neuroscience

    Amyotrophic Lateral Sclerosis: Marking the differences in motoneurons

    Simon A Sharples, Patrick J Whelan
    A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.
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