361 results found
    1. Immunology and Inflammation

    The kinase PDK1 is critical for promoting T follicular helper cell differentiation

    Zhen Sun et al.
    PDK1 serves as a critical role for intrinsically promoting T follicular helper cell differentiation and effector functions via controlling expression level of TCF1.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

    Patrick T Dolan et al.
    Distinct selective landscapes in mosquito and human cells shape dengue virus genetic diversity and highlight mechanisms of host adaptation in arboviruses.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou et al.
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Physics of Living Systems

    Charge-driven condensation of RNA and proteins suggests broad role of phase separation in cytoplasmic environments

    Bercem Dutagaci et al.
    Charge complementarity between RNA and proteins may be a universal principle for phase separation in biology without requiring disorder or specific multivalent interactions.
    1. Neuroscience

    Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations

    Limei Zhang et al.
    Placing the PACAP/PAC1 signaling within glutamate/GABA cell type and subregional contexts in mouse brain reveals its conspicuous role for sensorimotor circuit interaction through modulating neuronal plasticity.
    1. Cell Biology

    TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

    Fernando R Balestra et al.
    TRIM37 prevents the formation of centriolar protein assemblies through an atypical de novo assembly pathway that would otherwise threaten genome integrity.
    1. Neuroscience

    Precisely timed dopamine signals establish distinct kinematic representations of skilled movements

    Alexandra Bova et al.
    Dopamine signaling gradually causes long-lasting changes in fine motor coordination that can later be activated by acute changes in dopamine neuron activity.
    1. Chromosomes and Gene Expression

    Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

    Evelyn L Eastwood et al.
    Heterochromatin formation at transposon loci depends on dimerisation of the effector complex that elicits co-transcriptional silencing and this requirement is fulfilled by co-option of the conserved dimerisation hub protein, Cut-up/LC8.
    1. Structural Biology and Molecular Biophysics

    Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

    Nadia Füllbrunn et al.
    The axial organization and dynamics of the HOPS complex at membrane surface are resolved by graphene-induced energy transfer with subnanometer resolution.

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