396 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

    Zhengjian Zhang et al.
    An inorganic tin oxochloride cluster specifically binds to an intrinsically disordered, histidine-rich, low complexity protein region and arrests de novo transcription initiation without affecting reinitiation.
    1. Cell Biology
    2. Computational and Systems Biology

    Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

    Taraneh Zarin et al.
    A statistical model systematically associates functions of intrinsically disordered regions with sequence-distributed molecular features such as charge, residue composition, or repeat content.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SON and SRRM2 are essential for nuclear speckle formation

    İbrahim Avşar Ilik et al.
    Re-characterization of the targets of a commonly used nuclear speckle marker unexpectedly leads to the discovery of the elusive core of the nuclear speckles.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23

    See-Yeun Ting et al.
    The motor that drives preproteins into the mitochondrial matrix is coupled to the translocase by Tim44, a two-domain scaffold protein with an intrinsically disordered "dynamic arm" and a structurally stable anchoring domain.
    1. Cell Biology
    2. Developmental Biology

    Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

    Helen Schmidt et al.
    P granule assembly depends in part on protein-protein interactions that drive condensation independent of RNA.
    1. Structural Biology and Molecular Biophysics

    Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

    Cristina Olivieri et al.
    A combination of NMR, fluorescence, and molecular dynamics simulations reveals the recognition mechanism for the intrinsically disordered regulator of protein kinase A, highlighting the enzyme's nuclear export process.
    1. Cell Biology

    Pak1 kinase controls cell shape through ribonucleoprotein granules

    Joseph O Magliozzi, James B Moseley
    A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.
    1. Cell Biology

    CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

    Jordina Guillén-Boixet et al.
    CPEB4's switch from translational repressor to activator is regulated during cell cycle by hyperphosphorylation of its intrinsically disordered domain, which controls its phase-separation into RNA-containing liquid-like droplets.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Pi-Pi contacts are an overlooked protein feature relevant to phase separation

    Robert McCoy Vernon et al.
    Statistics on the frequencies of pi interactions in folded protein structures enable successful prediction of intrinsically disordered protein phase separation, with clear implications for a physical understanding of cellular organization.
    1. Developmental Biology

    A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes

    Michelle A Carmell et al.
    GCNA proteins comprise a previously unnoticed family of proteins that has been enriched in cells carrying a heritable genome since the invention of sexual reproduction in eukaryotes, and has had reproductive function for at least 600 million years.

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