NALCN and TRPC6 drive the subthreshold depolarization of VTA DA neurons and down regulation of TRPC6 contributes to reduced VTA DA neuron firing and chronic stress-induced depression-like behavior of mice.

Computational modeling suggests that the BLA is capable of producing the recorded LFP rhythms via interactions of interneuron subtypes, and that those rhythms may be necessary for associative learning.

Proteins in the Transmembrane Channel-Scramblase (TCS) superfamily share an evolutionarily conserved ability to permeate ions and phospholipids, challenging distinctions between ion channels and lipid scramblases.

Engineered anion-conducting channelrhodopsins with enhanced red-light sensitivity and accelerated kinetics enable precise, low-intensity optical silencing of neurons, advancing optogenetic control in neuroscience research.

The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.

A combination of high-resolution structure determination, electrophysiology, and MD simulations reveal fundamental insight into the molecular function of voltage-gated chloride channels.

Potassium presumably binds to the Na1 site in LeuT, playing a role in inwardly rectifying the transport of substrates.

Close friend quantity is nonlinearly associated with various mental health and cognitive outcomes in children and could be partly explained by the structure of the social brain and the endogenous opioid system.

Intracellular NASPM, unlike the widely used spermine, fully blocks outward currents through calcium-permeable AMPA-type glutamate receptors, enabling an improved functional readout for this physiologically important receptor subtype in neurons.