Browse the search results

Page 2 of 677
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

    Anirban Banerjee et al.
    Charybdotoxin, a toxin produced by scorpions, blocks a K+ channel by binding in a lock-and-key fashion to the mouth of the channel and presenting a lysine amino group, which serves as a K+ mimic in the selectivity filter.
    1. Structural Biology and Molecular Biophysics

    Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

    Zhe Zhang et al.
    The 3Å structure and correlated functional analysis of the TRPM2 cation channel from Nematostella vectensis shed light on the molecular mechanisms of TRPM2 regulation by intra- and extracellular Ca2+, and of inactivation of human TRPM2.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Sculpting ion channel functional expression with engineered ubiquitin ligases

    Scott A Kanner et al.
    Engineered E3 ubiquitin ligases are utilized to elucidate mechanisms underlying ubiquitin regulation of membrane proteins, and to achieve robust post-translational functional knockdown of ion channels.
    1. Genetics and Genomics
    2. Neuroscience

    The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti

    Benjamin J Matthews et al.
    The ion channel ppk301 is required for the evaluation of water purity during egg-laying, which promotes offspring survival in the arboviral vector mosquito Aedes aegypti.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin

    Alexandria N Miller et al.
    Cryo-EM structures of the gating cycle of bestrophin reveal the molecular underpinnings of activation and inactivation gating in this calcium-activated chloride channel and reveal a surprisingly wide pore.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

    Swetha E Murthy et al.
    A family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels has been characterized in plants, flies, and mammals.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

    David M Kern et al.
    The basis for small-molecule block, insights into gating, and an unexpected architectural role for the lipid membrane are revealed in structures of the volume regulated anion channel LRRC8A.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Atypical calcium regulation of the PKD2-L1 polycystin ion channel

    Paul G DeCaen et al.
    Outward calcium ion currents desensitize the human PKD2-L1 ion channel via a mechanism that is independent of cytosolic motifs.
    1. Structural Biology and Molecular Biophysics

    Mechanistic signs of double-barreled structure in a fluoride ion channel

    Nicholas B Last et al.
    Combining crystal structures with single-pore analysis of Fluc-family fluoride channel mutants demonstrates that Fluc channels have two separate fluoride ion permeation pathways within the channel complex.
    1. Physics of Living Systems
    2. Neuroscience

    Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

    Amanda H Lewis, Jörg Grandl
    Tension is the activating stimulus of Piezo1 mechanosensitive ion channels and resting membrane tension modulates overall channel sensitivity to mechanical stimulation.