Drosophila DM1 models suggest that elevated cardiac expression of straightjacket/α2δ3, a regulatory subunit of voltage-gated calcium channel, contributes to cardiac conduction defects in DM1.

Leptin acts in the paraventricular nucleus to slowly increase sympathetic nerve activity to skeletal muscle and brown adipose tissue via induction of its own receptor in TRH glutamatergic neurons.

A specialized conduction pathway for the electrical impulse in the heart, previously thought to be associated with the endothermic mammals and birds only, is also present in the ectothermic crocodiles.

Infrared laser-mediated gene induction microscopy enables precise single-cell labeling in various tissues of zebrafish, and in vivo visualized single-cell lineage tracing reveals the lineage heterogeneity in hematopoietic endothelial cells.

Conduction velocity of action potentials in unmyelinated axons depends ultimately on the gating variables of the fast voltage-gated sodium current and can be predicted from the action potential peak and trough voltages.

Biochemical and genetic studies reveal a third transcription factor, BHLHE40, that together with LXR and C/EBPβ mediates insulin induction of SREBP-1c, which in turn leads to triglyceride accumulation in liver.

Ion conduction in the calcium-activated chloride channel TMEM16A is directly regulated by calcium, which binds to a site close to the pore thereby shaping the electrostatics at its intracellular entrance.

While activated by a common mechanism, both functions in TMEM16F - lipid scrambling and ion conduction - are likely mediated by alternate protein conformations that are at equilibrium in the ligand-bound state.

Biologically plausible changes in the excitabilities of single neurons may suffice to selectively modulate sequential network dynamics, without modifying of recurrent connectivity.

Single-particle cryo-EM and electrophysiology studies of the chloride channel TMEM16A reveals the structural basis for anion conduction and uncover its relationship to lipid scramblases of the same family.