TMEM16F shifts its ion selectivity in response to change of intracellular Ca²⁺, membrane potential and ionic strength.

A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.

Sodium selectivity of acid-sensing ion channels is mediated by negatively charged side chains and not by a size-exclusion mechanism.

ON and OFF visual motion is computed with the same algorithm despite differences in circuit architecture.

The TRPV1, TRPV2 and TRPV3 channels are gated on the cytosolic side of the pore, whereas structural changes in the ion selectivity filter associated with activation don't control cation access.

Experimental and computational models reveal how parallel 'core' mechanisms shape direction selectivity at the dendrites of starburst amacrine cells and ganglion cells in the mouse retina.

Emx2 mediates the directional selectivity of neuromasts by regulating hair bundle orientation in hair cells, and by selecting afferent neuronal targets.

Not all members of the bacteria sodium channel family are sodium channels - those found in Bacillus are highly adaptable and can be converted into many selectivity types.

A common mechanism for computation of direction selectivity in the ON and OFF channel is demonstrated.

The small glycine residue in the Cav selectivity filter is an overlooked feature that determines Ca²⁺ selectivity and provides new insight into the Ca²⁺ selectivity mechanism conserved from prokaryotes to eukaryotes.