370 results found
    1. Medicine
    2. Neuroscience

    APOE2 is associated with longevity independent of Alzheimer’s disease

    Mitsuru Shinohara et al.
    Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.
    1. Genetics and Genomics

    NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

    Gabriel A Guerrero et al.
    Separate genetic pathways mediate longevity, pathogen resistance, and cell-nonautonomous regulation of xenobiotic detoxification in chemosensory defective Caenorhabditis elegans mutants.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Cell Biology
    2. Developmental Biology

    Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

    Moran Cohen-Berkman et al.
    Endo-siRNAs slow down the rate of aging and enable the maintenance of a responsive heat shock response in aging germline-less Caenorhabditis elegans.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

    Wenke Wang et al.
    Two SET-domain containing proteins regulate H3K4me3 by their binding to H3K4me3 through their PHD domain and directly regulate expression of a subset of genes.
    1. Cell Biology

    Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell

    Sandro Baldi et al.
    To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

    Zaijun Ma et al.
    Epigenetic drift of H3K27me3 is one of the molecular mechanisms that contribute to aging, and stimulation of glycolysis promotes metabolic health and longevity.
    1. Cell Biology

    Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

    Yanan Sun et al.
    Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
    1. Developmental Biology

    Optogenetic control of gut bacterial metabolism to promote longevity

    Lucas A Hartsough et al.
    Light controls can fine tune microbiome–host interaction to qualitatively regulate host longevity with temporal and spatial precision.
    1. Ecology
    2. Epidemiology and Global Health

    Personality links with lifespan in chimpanzees

    Drew M Altschul et al.
    Among captive chimpanzees, higher agreeableness males and higher openness females survive longer.

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