355 results found
    1. Neuroscience

    Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation

    Xiling Li et al.
    Genetic and electrophysiological analyses reveal that the mechanisms orchestrating the induction and expression of homeostatic plasticity are compartmentalized and operate with exquisite specificity on both sides of the synapse.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits

    Jodi A Hadden et al.
    All-atom molecular dynamics of the HBV capsid supports a role for structural asymmetry in biological function, reveals the potential for triangular pores to mediate cellular signaling, and indicates that capsid flexibility may limit resolution attainable by cryo-EM.
    1. Computational and Systems Biology
    2. Neuroscience

    Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures

    Gautam Reddy et al.
    Computational and theoretical analyses offer novel and unexpected insight into how complex, naturally occurring odor mixtures are parsed and normalized at the very first stage of olfaction.
    1. Neuroscience

    Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network

    Andrea Ferrario et al.
    A new probabilistic model of connectivity reveals the structural and functional properties of the neural networks controlling locomotion in many individual tadpoles.
    1. Neuroscience

    Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

    Chang-Hui Tsao et al.
    Mushroom bodies are a hunger and satiety integrative center that controls food-seeking behavior in Drosophila..
    1. Neuroscience

    Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons

    Lei Xiao et al.
    Oxytocin, a peptide linked to the processing of socially meaningful stimuli, modulates excitatory synaptic transmission in dopaminergic neurons of ventral tegmental area via retrograde endocannabinoid signaling, acting as a pathway-specific temporal filter for synaptic inputs.
    1. Neuroscience

    Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

    Valerie A Larson et al.
    Oligodendrocytes in white matter use Kir4.1 inwardly rectifying potassium channels to prevent extracellular potassium accumulation, enabling neurons to sustain repetitive firing and limiting the initiation of seizures.
    1. Neuroscience

    Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei

    Rashmi Sarnaik, Indira M Raman
    Stride-related modulated firing by neurons of the cerebellar nuclei is required for smooth execution of practiced locomotion and persists more easily with synchronous than asynchronous Purkinje-mediated inhibition.
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Structural Biology and Molecular Biophysics

    Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

    Tatsuro Maruyama et al.
    Nuclear magnetic resonance analysis revealed the structural and dynamical changes in MgtE during the channel closure caused by the cooperative Mg2+-binding, which had remained undescribed only by a static crystal structure.

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