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    1. Biochemistry and Chemical Biology

    Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

    Peter Ahorukomeye et al.
    The unique modus operandi of cone snail venom insulins provides new insight into insulin receptor activation and informs on the design of insulin analogs for the treatment of diabetes.
    1. Neuroscience

    High-order thalamic inputs to primary somatosensory cortex are stronger and longer lasting than cortical inputs

    Wanying Zhang, Randy M Bruno
    Secondary thalamic nuclei may provide stronger, longer-lasting input to superficial layers of primary sensory cortex than other cortical areas can.
    1. Neuroscience

    Humans strategically shift decision bias by flexibly adjusting sensory evidence accumulation

    Niels A Kloosterman et al.
    Decision-makers are able to intentionally control neural excitability to strategically bias sensory evidence accumulation towards the decision bound that maximizes reward within a given ecological context.
    1. Neuroscience

    Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing

    Hao Li et al.
    Rostromedial tegmental neurons encode motivational valence and opponent responses across a wide range of affective stimulus modalities, while also driving dopamine inhibition and conditioned place aversion to aversive stimuli.
    1. Neuroscience

    Computational modeling of brainstem circuits controlling locomotor frequency and gait

    Jessica Ausborn et al.
    A new computational model of brainstem control of locomotor speed and gait was developed to reproduce and explain recent experimental data and propose predictions for subsequent experimental testing.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The role of scaffold reshaping and disassembly in dynamin driven membrane fission

    Martina Pannuzzo et al.
    Computational modeling of a dynamin-constricted membrane neck can rank proposed shape changes of the helical scaffold in terms of their fission aptitude and elucidate the associated pathways.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

    Charles B Phillips et al.
    Biochemical analysis reveals molecular mechanisms underlying the activation of the mitochondrial Ca2+ uniporter by intracellular Ca2+ signals.
    1. Neuroscience

    Thalamic reticular control of local sleep in mouse sensory cortex

    Laura MJ Fernandez et al.
    Local cortical sleep features arise subcortically due to heterogeneous burst discharge in neurons of a sleep rhythm pacemaker previously thought to act uniformly.
    1. Physics of Living Systems

    High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

    Asher Preska Steinberg et al.
    Polymers from dietary fiber can control the aggregation of particulates in the murine small intestine in a manner qualitatively consistent with depletion interactions.
    1. Neuroscience

    Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning

    Shinji Urata et al.
    A method of generating comprehensive maps of cochlear cells was created and enabled researchers to study characteristics of cellular damage in aged and noise-exposed inner ear.